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A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

2025-04-07

Abstract excerpt

Alpha-ketoglutarate (αKG) is required for chromatin demethylation but mechanisms controlling αKG abundance in the nucleus are poorly defined. Therefore, we designed a biosensor system to monitor this metabolite pool in human cells using an αKG-responsive cyanobacterial transcription factor, NtcA. We then coupled this system with a genetic screen to identify genes that regulate αKG in the nucleus, defining an inter...

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Literature Corpus work
63c72615-f050-5eff-857e-e15a6d5d60eb
DOI
10.1101/2025.04.06.647450
Open publication

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A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatinDOI 10.1101/2025.04.06.647450
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