Article

DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma

2021-11-04

Abstract excerpt

Ewing sarcoma is the second most common bone malignancy in children and adolescents. Patients with upfront metastatic or recurrent disease have poor outcomes with 5-year survival rates of <30%. CDC7, also known as DDK (DBF4-dependent kinase), is a serine-threonine kinase that, in coordination with its activation subunit ASK (or DBF4), is involved in a diverse array of cellular functions including the regulation of...

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Literature Corpus work: 63c62320-e8ec-5d8f-b088-8253444b4d3a
DOI: 10.1101/2021.11.02.466939

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