Article

Decreased CREB phosphorylation impairs embryonic retinal neurogenesis in the <i>Oa1-/-</i> mouse model of Ocular albinism

2024-05-14

Abstract excerpt

<h4>Summary</h4> Mutations in the human Ocular albinism type-1 gene OA1 are associated with abnormal retinal pigment epithelium (RPE) melanogenesis and poor binocular vision resulting from misrouting of ipsilateral retinal ganglion cell (iRGC) axons to the brain. We studied the latter using wild-type (WT) and Oa1-/- mouse eyes. At embryonic stages, the WT RPE-specific Oa1 protein signals through cAMP/Epac1-Erk2...

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Literature Corpus work: 6372a0bd-9695-5278-815c-be0802c35652
DOI: 10.1101/2024.05.14.594013

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