Article
Crb1 is a determinant of retinal apical Müller glia cell features.
Glia - 1 Nov 2007
van de Pavert Serge A, Sanz Alicia Sanz, Aartsen Wendy M, Vos Rogier M, Versteeg Inge, Beck Susanne C, Klooster Jan, Seeliger Mathias W, Wijnholds Jan
Abstract excerpt
Mutations in the human Crumbs homologue-1 (CRB1) gene cause retinal blinding diseases, such as Leber congenital amaurosis and retinitis pigmentosa. In the previous studies we have shown that Crb1 resides in retinal Müller glia cells and that loss of Crb1 results in retinal degeneration (particularly in the inferior temporal quadrant of the mouse eye). Degeneration is increased by exposure to white light. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.