Article

MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy

2022-09-20

Abstract excerpt

<title>Abstract</title> <p>Pyruvate is an essential metabolite produced by the glycolytic pathway in the cytosol and must be transported across the inner mitochondrial membrane (IMM) into the mitochondrial matrix, where it is oxidized to fuel mitochondrial respiration. Pyruvate import is performed by Mitochondrial Pyruvate Carrier (MPC), which is a hetero-oligomeric complex composed by interdependent subunits MPC...

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Literature Corpus work: a5537325-eef5-50ec-92e0-11238dfef30e
DOI: 10.21203/rs.3.rs-2069607/v1

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