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Article

Structural basis of the dysfunctioning of human 2-oxo acid dehydrogenase complexes.

Current medicinal chemistry - 1 Feb 2002

Hengeveld A F, de Kok A

Abstract excerpt

2-oxo acid dehydrogenase complexes are a ubiquitous family of multienzyme systems that catalyse the oxidative decarboxylation of various 2-oxo acid substrates. They play a key role in the primary energy metabolism: in glycolysis (pyruvate dehydrogenase complex), the citric acid cycle (2-oxoglutarate dehydrogenase complex) and in amino acid catabolism (branched-chain 2-oxo acid dehydrogenase complex)....

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PMID: 11945122
DOI: 10.2174/0929867023370996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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