Article

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo

2025-09-04

Abstract excerpt

<h4>Summary</h4> The atrioventricular node (AVN) ensures synchronized heart contractions by establishing the electrical connection between the atria and ventricles. Dysfunction of the pacemaker cells of the AVN leads to atrioventricular block (AV block), a life-threatening condition managed with electronic pacemakers (EPMs). EPMs have drawbacks that could be overcome by a human pluripotent stem cell (hPSC)-derive...

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Literature Corpus work: 633c6f13-40b8-5236-884c-06b572db9764
DOI: 10.1101/2025.09.04.674322

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