Knockdown of STAU1 inhibits inflammation and autophagy in in vitro chronic obstructive pulmonary disease model by regulating AMPK–mTOR signaling pathway

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, airway obstruction, and lung damage, often triggered by cigarette smoke. Dysregulated autophagy and inflammation are key contributors to its progression. Although double-stranded RNA-binding protein Staufen homolog 1 (STAU1), a multifunctional protein primarily involved in mRNA transport and localization, is identified as a...

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