Article

Loss of adaptive capacity in asthmatics revealed by biomarker fluctuation dynamics upon experimental rhinovirus challenge

2019-07-02

Abstract excerpt

Asthma is a dynamic disease, in which lung mechanical and inflammatory processes often interact in a complex, unpredictable manner. We hypothesize that this may be explained by respiratory disease-related systems instability and loss of adaptability to changing environmental conditions, resulting in highly fluctuating biomarkers and symptoms. Using time series of inflammatory (eosinophils, neutrophils, FeNO), clin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62ec7fa7-1fb5-57d0-917b-2633e13032f0
DOI: 10.1101/684910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of adaptive capacity in asthmatics revealed by biomarker fluctuation dynamics upon experimental rhinovirus challengeDOI 10.1101/684910Read

Temporal complexity in clinical manifestations of lung disease.Semantic proximity Read

Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants.Semantic proximity Read

Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosaSemantic proximity Read

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammationSemantic proximity Read

Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet.Semantic proximity Read

Epithelial cell responses to rhinovirus identify an early-life-onset asthma phenotype in adults.Semantic proximity Read

Stability of inflammatory phenotypes in asthmaSemantic proximity Read

Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.Semantic proximity Read

Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children.Semantic proximity Read

Analyzing phenotypes post-exposure in allergic rhinitis in the environmental exposure unit.Semantic proximity Read

A Mixed T2/T17-Associated Systemic Immune Signature Links Airborne Pollutant Exposure to Persistent Respiratory SymptomsSemantic proximity Read

Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamicsSemantic proximity Read