Article
Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017
Valentino Elena, Bellazzo Arianna, Di Minin Giulio, Sicari Daria, Apollonio Mattia, Scognamiglio Giosuè, Di Bonito Maurizio, Botti Gerardo, Del Sal Giannino, Collavin Licio
Abstract excerpt
Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequent event and a significant factor in cancer development and progression. Mutant p53 protein(s) (mutp53) can acquire...
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