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Article

Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling.

Cancer chemotherapy and pharmacology - 1 Aug 2023

Zhou Xinghua, Kang Jian, Zhang Liangliang, Cheng Yue

Abstract excerpt

PURPOSE: Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation. Intriguingly, KRAS-mutant cancers are particularly vulnerable to ferroptosis. Osthole is a natural coumarin extracted from Cnidium spp. and other Apiaceous plants. In the present study, we explored the antitumor potential of osthole in KRAS-mutant colorectal cancer (CRC) cells. METHODS: Cell viability assay, EdU...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37318525
DOI: 10.1007/s00280-023-04549-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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