Back to search

Article

Comparative 3D genome analysis between neural retina and RPE reveals differential <i>cis</i> -regulatory interactions at retinal disease loci

2023-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Vision depends on the functional interplay between the photoreceptor cells of the neural retina and the supporting cells of the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases (IRD) display highly specific spatiotemporal expression within these interconnected retinal components through the local recruitment of cis -regulatory elements (CREs) in 3D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
62d0ff35-9af5-5613-87e1-488e506547ca
DOI
10.1101/2023.06.20.543842
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative 3D genome analysis between neural retina and RPE reveals differential <i>cis</i> -regulatory interactions at retinal disease lociDOI 10.1101/2023.06.20.543842
Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal <i>Cis</i> -Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic VariationSemantic proximity
Single-cell analysis of the epigenome and 3D chromatin architecture in the human retinaSemantic proximity
Multi-omics analysis in human retina uncovers ultraconserved <i>cis</i> -regulatory elements at rare eye disease lociSemantic proximity
Integrated multi-omics single cell atlas of the human retinaSemantic proximity
Multi-omics profiling, <i>in vitro</i> and <i>in vivo</i> enhancer assays dissect the <i>cis</i> -regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathySemantic proximity
Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease RiskSemantic proximity
Integrated multi-omics single cell atlas of the human retinaSemantic proximity
A conserved enhancer cluster regulates <i>efnb2</i> expression in the vertebrate dorsal retinaSemantic proximity
Analysis of gene network bifurcation during optic cup morphogenesis in zebrafishSemantic proximity
Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease.Semantic proximity
Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoidsSemantic proximity
Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseasesSemantic proximity
Select a neighboring publication to make it the new centre.