Article

Autoimmunity and <i>H. pylori</i> infection cooperatively promote epithelial tumorigenic differentiation and systemic immune modulation

2025-11-26

Abstract excerpt

<h4>Background and Aims</h4> Gastric cancer (GC) demographics have shifted, with a growing impact on younger populations, particularly women. Chronic Helicobacter pylori (HP) infection is the leading risk factor for GC; however, decreasing HP prevalence means it is unlikely the cause of rising incidence of early-onset GC. Autoimmunity, which is more prevalent in women, has been proposed as a contributing factor....

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Literature Corpus work: 62c67d20-ea2d-5bf0-9e31-b618589fa44c
DOI: 10.1101/2025.11.23.690054

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