Article

Developing an in vitro model for investigating the effects of the HSV-1 latency-associated ncRNAs in human neurons

2020-01-01

Abstract excerpt

Herpes simplex virus 1 (HSV-1) persists for the lifetime of the host due to establishing latency in sensory neurons. During latency, the only abundantly transcribed HSV-1 gene is the latency-associated transcript (LAT), which is processed into the 1.5kb or 2.0kb major LAT intron and several microRNAs. These latency-associated non-coding RNAs (ncRNAs) have been reported to impact the establishment, maintenance and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6296e14a-b0d7-5ca2-925b-5dbc4e4e1424
DOI: 10.25560/90392

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Developing an in vitro model for investigating the effects of the HSV-1 latency-associated ncRNAs in human neuronsDOI 10.25560/90392Read

Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived NeuronsSemantic proximity Read

Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation In VivoSemantic proximity Read

Mechanisms of HSV gene regulation during latency and reactivationSemantic proximity Read

Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of LatencySemantic proximity Read

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?Semantic proximity Read

Identification of Viral MicroRNAs Expressed in Human Sacral Ganglia Latently Infected with Herpes Simplex Virus 2Semantic proximity Read

HSV LAT and neuronal survival.Semantic proximity Read

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent InfectionSemantic proximity Read

Establishing a Herpesvirus Quiescent Infection in Differentiated Human Dorsal Root Ganglion Neuronal Cell Line Mediated by Micro-RNA OverexpressionSemantic proximity Read

An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factorSemantic proximity Read

Expression of Herpes Simplex Virus 1 MicroRNAs in Cell Culture Models of Quiescent and Latent InfectionSemantic proximity Read

Neuronal miR-138 Represses HSV-2 Lytic Infection by Regulating Viral and Host Genes with Mechanistic Differences from HSV-1Semantic proximity Read