Article

Mechanistic Modeling Explains the Production Dynamics of Recombinant Adeno-Associated Virus with the Baculovirus Expression Vector System

2023-02-05

Abstract excerpt

The demand for recombinant adeno-associated virus (rAAV) for gene therapy is expected to soon exceed current manufacturing capabilities, considering the expanding number of approved products and of pre-clinical and clinical stage studies. Current rAAV manufacturing processes have less-than-desired yields and produce a significant amount of empty capsids. Recently, FDA approved the first rAAV-based gene therapy pro...

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Literature Corpus work: 628f4a5b-1d28-5d81-b56d-cec2f8cf4f5c
DOI: 10.1101/2023.02.04.527082

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