Article

miR-486-3p ameliorates aging-related impaired angiogenesis in adult moyamoya disease by targeting Forkhead Box O4

2025-05-12

Abstract excerpt

<h4>Objective</h4> Investigate miR-486-3p’s role in alleviating age-related angiogenic decline in Moyamoya disease (MMD) by regulating senescent endothelial cells. <h4>Methods</h4> Clinical analysis of 151 MMD patients correlated age with postoperative angiogenesis (DSA grading). Senescent HUVECs (SA-β-gal>80%) exhibited elevated SASP factors (IL-6/IL-8/MCP-1). Functional assays (EdU/Transwell/Matrigel) and bioi...

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Literature Corpus work: 625aa523-d87d-5faf-9979-271cda32dc9b
DOI: 10.1101/2025.05.07.652777

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