Article

Chemical inhibition of SUMOylation activates the FSHD locus

2025-08-02

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and debilitating muscle disease for which no cure currently exists. In the majority of cases, FSHD is associated with the contraction of the D4Z4 macrosatellite repeat array at the 4q35 locus, leading to the inappropriate activation of DUX4 , normally expressed during early embryogenesis. In FSHD, the genetic contraction is accompanied by hypomethylat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d64b13e-b4f9-518a-84e1-80cab0099e67
DOI: 10.1101/2025.08.01.668136

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chemical inhibition of SUMOylation activates the FSHD locusDOI 10.1101/2025.08.01.668136Read

Loss of epigenetic silencing of the DUX4 transcription factor gene in facioscapulohumeral muscular dystrophy.Semantic proximity Read

Oligonucleotide Therapies for Facioscapulohumeral Muscular Dystrophy: Current Preclinical LandscapeSemantic proximity Read

Facioscapulohumeral Muscular DystrophySemantic proximity Read

Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy.Semantic proximity Read

Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible TreatmentsSemantic proximity Read

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4Semantic proximity Read

The FSHD atrophic myotube phenotype is caused by DUX4 expression.Semantic proximity Read

FSHD Therapeutic Strategies: What Will It Take to Get to Clinic?Semantic proximity Read

Facioscapulohumeral muscular dystrophy: molecular pathological advances and future directions.Semantic proximity Read

SUMOylation differentially regulates SMCHD1 complex formation and function in a genomic context-specific mannerSemantic proximity Read

FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.Semantic proximity Read

Gene Editing to Tackle Facioscapulohumeral Muscular DystrophySemantic proximity Read