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Article

Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.

Cell host & microbe - 8 Jul 2020

Sorbara Matthew T, Littmann Eric R, Fontana Emily, Moody Thomas U, Kohout Claire E, Gjonbalaj Mergim, Eaton Vincent, Seok Ruth, Leiner Ingrid M, Pamer Eric G

Abstract excerpt

Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by producing short-chain fatty acids, converting primary to secondary bile acids, and facilitating colonization resistance against intestinal pathogens. To increase our understanding of genomic and functional diversity between members of this family, we...

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Identifiers

PMID: 32492369
DOI: 10.1016/j.chom.2020.05.005
PMCID: PMC7351604

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