Article

Mining Microbial Transcriptomes to Engineer Cell-Based Bacterial Biosensors in Gut-Resident Bacteroidaceae

2026-08-11

Abstract excerpt

<h4>Summary</h4> The gastrointestinal tract is rich in metabolic, immune, and microbiome-derived signals that can inform the design of live biotherapeutics and diagnosis of intestinal disorders. Engineered cell-based biosensors can tap into this molecular information and report on their environment, yet their development in gut-resident symbionts has been limited by a lack of validated sensor systems. Here, we pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1379aa31-56e9-5403-bd0c-49b756285c05
DOI: 10.64898/2026.08.10.744002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mining Microbial Transcriptomes to Engineer Cell-Based Bacterial Biosensors in Gut-Resident BacteroidaceaeDOI 10.64898/2026.08.10.744002Read

Synthetic gene circuits enable systems-level biosensor discovery at the host-microbe interfaceSemantic proximity Read

A discovery platform to identify inducible synthetic circuitry from varied microbial sourcesSemantic proximity Read

Implementation of Probiotic Bacteria for Monitoring Intestinal InflammationSemantic proximity Read

Probe-based bacterial single-cell RNA sequencing predicts toxin regulationSemantic proximity Read

Expanding the <i>Bacteroides</i> synthetic biology toolkit to develop an <i>in vivo</i> intestinal malabsorption biosensorSemantic proximity Read

Surveying the Genetic Design Space for Transcription Factor-Based Metabolite Biosensors: Synthetic Gamma-Aminobutyric Acid and Propionate Biosensors in E. coli Nissle 1917Semantic proximity Read

Unveiling the hidden biodiversity of microbial chemoreceptor genes in the rare biosphereSemantic proximity Read

Droplet-based single cell RNA sequencing of bacteria identifies known and previously unseen cellular statesSemantic proximity Read

Diagnostic and Therapeutic Microbial Circuit with Application to Intestinal InflammationSemantic proximity Read

Droplet-based single cell RNA sequencing of bacteria identifies known and previously unseen cellular statesSemantic proximity Read

Engineering butyrate-producing Lachnospiraceae to treat metabolic diseaseSemantic proximity Read

Leveraging a new data resource to define the response of <i>C. neoformans</i> to environmental signalsSemantic proximity Read