Article

Light weight deep learning-based auto-quantification system for bright-filed HER2 dual in situ hybridization image analysis

2025-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The evaluation of erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) gene amplification status through Dual in Situ Hybridization (DISH) currently relies on manual assessment by pathologists. There are several deep learning-based algorithms for H&E or ISH analysis. However, DISH analysis tools are still lacking. We developed a fully automated deep learning-based quantification system to assist pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60ff4a22-a7a8-56d2-8d8f-8640a138b62b
DOI: 10.1101/2025.07.27.25331550

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Light weight deep learning-based auto-quantification system for bright-filed HER2 dual in situ hybridization image analysisDOI 10.1101/2025.07.27.25331550Read

Deep learning to automatically evaluate HER2 gene amplification status from fluorescence in situ hybridization imagesSemantic proximity Read

Automated detection of the HER2 gene amplification status in Fluorescence <i>in situ</i> hybridization images for the diagnostics of cancer tissuesSemantic proximity Read

Comparison of the classification of HER2 from whole-slide images between pathologists and a deep learning modelSemantic proximity Read

A deep learning-based iterative digital pathology annotation toolSemantic proximity Read

Image analysis for bright-field HER2 in situ hybridization: validation for clinical useSemantic proximity Read

Automated HER2 scoring in breast cancer HE-stained images using hybrid deep learning ensemble and probabilistic optimizationSemantic proximity Read

Updated 2013 College of American Pathologists/American Society of Clinical Oncology (CAP/ASCO) guideline recommendations for human epidermal growth factor receptor 2 (HER2) fluorescent in situ hybridization (FISH) testing increase HER2 positive and HER2 equivocal breast cancer cases; retrospective study of HER2 FISH results of 836 invasive breast cancersSemantic proximity Read

Assessing the risk of recurrence in early-stage breast cancer through H&E stained whole slide imagesSemantic proximity Read

Comparative Analysis of HER2 Immunohistochemistry (IHC) and Brightfield Dual-Color In Situ Hybridization (DISH) in Lymph Node Metastasized Breast CancerSemantic proximity Read

Computer-aided scoring of erb-b2 receptor tyrosine kinase 2 (HER2) gene amplification status in breast cancerSemantic proximity Read

Automated brightfield break-apart in situ hybridization (ba-ISH) application: ALK and MALT1 genes as modelsSemantic proximity Read

Validation of Dual-Color Dual In Situ Hybridization for HER2/neu Gene in Breast CancerSemantic proximity Read