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Image analysis for bright-field HER2 in situ hybridization: validation for clinical use

7 Aug 2024

Abstract excerpt

Abstract The aim of the present study was to develop and validate a quantitative image analysis (IA) algorithm to aid pathologists in assessing bright-field HER2 in situ hybridization (ISH) tests in solid cancers. A cohort of 80 sequential cases (40 HER2-negative and 40 HER2-positive) were evaluated for HER2 gene amplification with bright-field ISH. We developed an IA algorithm using the ISH Module from HALO...

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PMID: 39107524
DOI: 10.1007/s00428-024-03889-3

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