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Validation of Dual-Color Dual In Situ Hybridization for HER2/neu Gene in Breast Cancer

25 Jul 2023

Abstract excerpt

CONTEXT.—: Human epidermal growth factor (HER2/neu) gene amplification, a poor prognostic factor in invasive breast cancer, has shown substantial utility as a predictive marker, with significantly improved survival following anti-HER2 therapies like trastuzumab. Dual-color dual in situ hybridization (D-DISH), a recently introduced fully automated assay for HER2/neu evaluation on light microscopy, has several...

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PMID: 37490416
DOI: 10.5858/arpa.2022-0543-oa

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