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A Proteome-Calibrated Mechanistic Digital Twin of the Glioblastoma Astrocyte Derived from Patient Multi-Omic Data

2026-04-23

Abstract excerpt

Digital twins of biological systems have been proposed as a framework for personalized medicine; however, existing implementations in oncology operate at the tissue or population scale with parameters derived from textbook kinetics rather than patient data. We describe a mechanistic digital twin of the glioblastoma (GBM) astrocyte in which all rate constants are calibrated to proteomic measurements from 50 wild-ty...

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Literature Corpus work
60a3d909-21e7-5521-a490-48162d9e96b3
DOI
10.64898/2026.04.23.719998
Open publication

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A Proteome-Calibrated Mechanistic Digital Twin of the Glioblastoma Astrocyte Derived from Patient Multi-Omic DataDOI 10.64898/2026.04.23.719998
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