Article

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics

2021-05-17

Abstract excerpt

Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of biomolecular data on cancer that now populates several online databases and resources. Cancer systems biology models built on top of this data have the potential to provide specific insights into complex multifactorial aberrations underpinning tumor initiation, development, and metastas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54490b0b-09db-59b4-8cb3-010a6d986370
DOI: 10.1101/2021.05.17.444410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized TherapeuticsDOI 10.1101/2021.05.17.444410Read

TISON: a next-generation multi-scale modeling theatre for <i>in silico</i> systems oncologySemantic proximity Read

A guide to identifying suitable patient-derived cancer models in CancerModels.OrgSemantic proximity Read

Interpretation of cancer mutations using a multiscale map of protein systems.Semantic proximity Read

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profilingSemantic proximity Read

Decoding Tumor Heterogeneity through Multi Omics: Insights into Cancer Evolution, Microenvironment and Therapy ResistanceSemantic proximity Read

Personalized Network Modeling of the Pan-Cancer Patient and Cell Line InteractomeSemantic proximity Read

Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.Semantic proximity Read

The crucial role of multiomic approach in cancer research and clinically relevant outcomesSemantic proximity Read

XENTURION, a multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients for population-level translational oncologySemantic proximity Read

dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal TumorsSemantic proximity Read

Future of personalized medicine in oncology: a systems biology approach.Semantic proximity Read

Molecular Characterization and Landscape of Breast cancer Models from a multi-omics PerspectiveSemantic proximity Read