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Tracking B cell responses to the SARS-CoV-2 mRNA-1273 vaccine

1 Jul 2023

Abstract excerpt

Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell analysis in three infection-naïve individuals. Integrated surface protein, transcriptomics, and B cell receptor (BCR) repertoire analysis of sorted plasmablasts and spike +...

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Identifiers

PMID: 37440409
DOI: 10.1016/j.celrep.2023.112780

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