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Article

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease

19 Jul 2016

Abstract excerpt

Friedreich's ataxia (FRDA), the most commonly inherited ataxia in populations of European origin, is a neurodegenerative disorder caused by a decrease in frataxin levels. One of the hallmarks of the disease is the accumulation of iron in several tissues including the brain, and frataxin has been proposed to play a key role in iron homeostasis. We found that the levels of zinc, copper, manganese and aluminum were...

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PMID: 27433942
DOI: 10.1371/journal.pone.0159209

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