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Article

Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia.

Gene - 1 Jun 2013

Soriano Sirena, Llorens José V, Blanco-Sobero Laura, Gutiérrez Lucía, Calap-Quintana Pablo, Morales M Puerto, Moltó M Dolores, Martínez-Sebastián M José

Abstract excerpt

Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we...

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Identifiers

PMID: 23542074
DOI: 10.1016/j.gene.2013.02.049

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IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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