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Article

Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment.

Biochimica et biophysica acta - 1 Jan 2000

Koopman Werner J H, Verkaart Sjoerd, van Emst-de Vries Sjenet E, Grefte Sander, Smeitink Jan A M, Nijtmans Leo G J, Willems Peter H G M

Abstract excerpt

Deficiency of mitochondrial NADH:ubiquinone oxidoreductase (complex I), is associated with a variety of clinical phenotypes such as Leigh syndrome, encephalomyopathy and cardiomyopathy. Circumstantial evidence suggests that increased reactive oxygen species (ROS) levels contribute to the pathogen...

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Source

Identifiers

PMID: 18435906
DOI: 10.1016/j.bbabio.2008.03.028

Genes

NDUFS1
NDUFS2
NDUFS7
NDUFS8
NDUFV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18435906-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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