Article

The Gly482Ser PPARGC1A polymorphism regulates PGC-1α stability and human brown adipocyte mitochondrial function under cold exposure

2024-12-03

Abstract excerpt

<title>Abstract</title> Adaptive thermogenesis in brown adipose tissue is regulated by PPARGC1A (PGC-1α), which could be affected by common polymorphism (rs8192678, Gly482Ser) that associates with metabolic disorders. We used CRISPR-Cas9 in immortalized human brown adipocyte cell line to edit the rs8192678 locus to evaluate the allele-dependent effects on cold response of brown adipocytes. In both 482Ser- and...

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Literature Corpus work: 604d8a89-983d-5897-9e1a-97b1421922a6
DOI: 10.21203/rs.3.rs-5219205/v1

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