Article

Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity

2004-01-01

Abstract excerpt

Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates suggests that MSI-H cancers are inherently more immunogenic. We aimed to compare the gene expression profiles of MSI-H and MSS cancers to provide evidence for an activated immune response in the former. We anal...

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Literature Corpus work: 5fcca0b0-a284-5516-a628-1b3d0dd5193b
DOI: 10.1186/1476-4598-3-21

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