Article
Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Jul 2009
Banerjea A, Hands R E, Powar M P, Bustin S A, Dorudi S
Abstract excerpt
OBJECTIVE: Colorectal cancers may demonstrate chromosomal instability (CSI) or microsatellite instability (MSI-H). A third group of microsatellite and chromosome stable (MACS) colorectal cancer has been described more recently. Patients with MSI-H colorectal cancers demonstrate improved outcome and a pronounced inflammatory infiltrate. Enhanced host immune response and increased immunogenicity might explain these...
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