Article

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

2026-02-20

Abstract excerpt

<h4>Objective</h4> Electronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet emulations often diverge from published RCT results. We hypothesized that these discrepancies are structured and learnable properties of a health system’s data-generating process, and that autonomous agentic workflows can generate discrepancies at the scale...

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Literature Corpus work: 124d4d7c-d9bb-55fd-ab59-e21ba8779904
DOI: 10.64898/2026.02.19.26346539

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