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MechAInistic: A Reviewer-Supervised Multi-Agent LLM System for Auditable Mechanistic Drug-Hypothesis Generation

2026-05-13

Abstract excerpt

<h4>SUMMARY</h4> LLM agents are increasingly used for scientific reasoning, but their fluent-sounding outputs can diverge from verifiable computational evidence, limiting their reliability for biomedical hypothesis generation. We developed MechAInistic, a multi-agent system in which an independently configured Reviewer agent supervises a planning Architect agent at each stage of the workflow, with all reasoning g...

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Literature Corpus work
ed3b8352-e208-5765-ad25-998a0aa06ba4
DOI
10.64898/2026.05.11.723319
Open publication

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