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Article

A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.

EMBO molecular medicine - 1 Jan 2018

Umoh Mfon E, Dammer Eric B, Dai Jingting, Duong Duc M, Lah James J, Levey Allan I, Gearing Marla, Glass Jonathan D, Seyfried Nicholas T

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlap in clinical presentation, neuropathology, and genetic underpinnings. The molecular basis for the overlap of these disorders is not well established. We performed a comparative unbiased mass spectrometry-based proteomic analysis of frontal cortical tissues from postmortem cases clinically defined as...

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Identifiers

PMID: 29191947
DOI: 10.15252/emmm.201708202
PMCID: PMC5760858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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