Article
[Pathophysiology of sideroblastic anemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024
Fujiwara Tohru
Abstract excerpt
Sideroblastic anemias (SAs) are a diverse group of congenital and acquired disorders, characterized by anemia and the presence of ring sideroblasts in bone marrow. Congenital SA is a rare disorder that results from genetic mutations that impair heme biosynthesis, iron-sulfur [Fe-S] cluster biosynthesis, and mitochondrial protein synthesis. The predominant type of congenital SA is X-linked sideroblastic anemia,...
Topics
- Anemia, Sideroblastic
- Humans
- Mutation
- 5-Aminolevulinate Synthetase
- Heme