Article
Two rare PROX1 variants in patients with lymphedema.
Molecular genetics & genomic medicine - 1 Oct 2020
Ricci Maurizio, Amato Bruno, Barati Shila, Compagna Rita, Veselenyiova Dominika, Kenanoglu Sercan, Stuppia Liborio, Beccari Tommaso, Baglivo Mirko, Kurti Danjela, Krajcovic Juraj, Serrani Roberta, Dundar Munis, Basha Syed H, Chiurazzi Pietro, Bertelli Matteo
Abstract excerpt
BACKGROUND: The PROX1 gene is specifically expressed in a subpopulation of endothelial cells that, by budding and sprouting, give rise to the lymphatic system. It also plays a critical role in neurogenesis and during development of many organs, such as the eye lens, liver, and pancreas. METHODS: We used next-generation sequencing (NGS) to sequence the DNA of a cohort of 246 Italian patients with lymphatic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.