Article

Loss of PERIOD2 (PER2) induces HO-1-mediated epithelial-mesenchymal transition and cisplatin resistance in Epi-A ovarian cancer

2024-10-17

Abstract excerpt

<title>Abstract</title> <p>Rapid metastasis and chemoresistance make ovarian cancer (OC) the deadliest gynecological cancer. These malignant phenotypes are strongly associated with epithelial-mesenchymal transition (EMT). OC is highly heterogenous with five distinct gene-expression based molecular subtypes (GEMS) correlated with different EMT levels and patient survival. However, the regulatory mechanisms underly...

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Literature Corpus work: 5e807afa-e22c-5f65-8716-3ecab45514db
DOI: 10.21203/rs.3.rs-5242949/v1

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