Article

Inherited extremes of aortic diameter confer risk for a specific class of congenital heart disease

2020-08-14

Abstract excerpt

Population based studies demonstrate strong familial recurrence of cardiac malformations particularly for individuals affected with a specific class of CHD, left-ventricular outflow tract (LVOT) obstruction. Recently we linked 99 lead variants across 71 loci to diameter of the ascending aorta derived from MRI measurements across multiple ethnicities in the UK Biobank. Using these data we created a polygenic risk s...

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Identifiers and source

Literature Corpus work: 5e781578-b203-5ebf-bfb7-e88cf58f82c4
DOI: 10.1101/2020.08.12.20172817

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