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Article

Aortic root aortopathy in bicuspid aortic valve associated with high genetic risk.

BMC cardiovascular disorders - 30 Aug 2021

Ma Mingjia, Li Zongzhe, Mohamed Mohamed Abdulkadir, Liu Ligang, Wei Xiang

Abstract excerpt

BACKGROUND: The bicuspid aortic valve (BAV) is prone to ascending aortic dilatation (AAD) involving both the tubular segment and the aortic root. The genetic factor was proposed as one of the most important mechanisms for AAD. We hypothesized that the rare genetic variants mainly contribute to the pathogenesis of aortic roots in affected individuals. METHODS: The diameter of aortic root or ascending aorta ≥ 40 mm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34461831
DOI: 10.1186/s12872-021-02215-y
PMCID: PMC8404252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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