Article

Refining the Diagnostic Accuracy of Parkinsonian Disorders using Metaphenomic Annotation of the Clinicopathological Literature

2023-12-14

Abstract excerpt

<h4>Background</h4> The diagnostic precision of Parkinsonian disorders is not accurate enough. Even in expert clinics up to one in five diagnoses are incorrect. This leads to cohorts with mixed pathologies, impacting our ability to understand disease heterogeneity and posing a major challenge for clinical trials. Gold standard diagnosis is post-mortem confirmation of the underlying proteinopathy, however many clin...

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Literature Corpus work: 734709b4-5fc1-5e7e-afba-9069b6d8adae
DOI: 10.1101/2023.12.12.23299891

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