Article

<i>Salmonella</i> Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages

2026-03-23

Abstract excerpt

Many intracellular pathogens stimulate host cell stress by directly or indirectly causing an imbalance in host nutrients; depletion of amino acid pools in particular can act as a danger signal to infected cells. Using a restrictive host model of Salmonella enterica serovar Typhi ( S. Typhi) infection, we identify early induction the integrated stress response (ISR) by viable bacteria, but not heat-killed bacteri...

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Literature Corpus work: 5e50de1f-d042-5a34-8644-b40b1edeed72
DOI: 10.64898/2026.03.16.712107

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