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Article

The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella -containing vacuole

4 Oct 2012

Abstract excerpt

Bacterial invasion results in the rapid induction of an acute state of cytosolic amino acid (AA) starvation, provoked by host membrane damage. Bacteria-induced AA starvation, in turn, down-regulates mTOR signaling while triggering autophagy and the integrated stress response pathway dependent on GCN2, eIF2α and ATF3. In Salmonella-infected cells, we now demonstrate that the host AA starvation response program...

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PMID: 23259056
DOI: 10.1242/bio.20122840

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