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Discovery of an anti-virulence compound that targets the <i>Staphylococcus aureus</i> SaeRS two-component system to inhibit toxic shock syndrome toxin 1 (TSST-1) production

2024-02-27

Abstract excerpt

Menstrual toxic shock syndrome (mTSS) is a rare but severe disorder associated with the use of menstrual products such as high-absorbency tampons and is caused by Staphylococcus aureus strains that produce the toxic shock syndrome toxin-1 (TSST-1) superantigen. Herein, we screened a library of 3920 small bioactive molecules for the ability to inhibit transcription of the TSST-1 gene without inhibiting growth of...

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Literature Corpus work
5e3ad90e-2eb8-513b-9f55-80f0ff6a9cee
DOI
10.1101/2024.02.27.582338
Open publication

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Discovery of an anti-virulence compound that targets the <i>Staphylococcus aureus</i> SaeRS two-component system to inhibit toxic shock syndrome toxin 1 (TSST-1) productionDOI 10.1101/2024.02.27.582338
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