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TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8 + T cells

22 Jan 2025

Abstract excerpt

ABSTRACT Toxic shock syndrome toxin-1 (TSST-1) is a superantigen produced by Staphylococcus aureus and is the determinant of menstrual toxic shock syndrome (mTSS); however, the impact of TSST-1 on the vaginal environment beyond mTSS is not understood. Herein, we assessed how TSST-1 affects vaginal colonization by S. aureus , host inflammatory responses, and changes in microbial communities within the murine...

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PMID: 39840991
DOI: 10.1128/iai.00439-24

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