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Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production

7 Jun 2024

Abstract excerpt

Menstrual toxic shock syndrome (mTSS) is a rare but severe disorder associated with the use of menstrual products such as high-absorbency tampons and is caused by Staphylococcus aureus strains that produce the toxic shock syndrome toxin-1 (TSST-1) superantigen. Herein, we screened a library of 3920 small bioactive molecules for the ability to inhibit transcription of the TSST-1 gene without inhibiting the growth...

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PMID: 38852884
DOI: 10.1016/j.jbc.2024.107455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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