Article

Analysis of the <i>Borreliaceae</i> Pangenome Reveals a Conserved Genomic Archictecture Across Phylogenetic Scales

2024-01-07

Abstract excerpt

The Family Borreliaceae contains arthropod-borne spirochetes that cause two widespread human diseases, Lyme disease (LD) and relapsing fever (RF). LD is a subacute, progressive illness with variable stage and tissue manifestations. RF is an acute febrile illness with prominent bacteremia that may recur and disseminate, particularly to the nervous system. Clinical heterogeneity is a hallmark of both diseases. Whil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e122855-434d-51ce-b771-43fa2a354329
DOI: 10.1101/2024.01.07.574540

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of the <i>Borreliaceae</i> Pangenome Reveals a Conserved Genomic Archictecture Across Phylogenetic ScalesDOI 10.1101/2024.01.07.574540Read

Whole genome sequencing of <i>Borrelia burgdorferi</i> isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulenceSemantic proximity Read

Characterization of the family-level Borreliaceae pan-genome and development of an episomal typing protocolSemantic proximity Read

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination.Semantic proximity Read

The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe.Semantic proximity Read

Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation.Semantic proximity Read

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing feverSemantic proximity Read

African Relapsing Fever Borreliae Genomospecies Revealed by Comparative GenomicsSemantic proximity Read

Whole-Genome Sequences of Thirteen Isolates of <i>Borrelia burgdorferi</i>Semantic proximity Read

Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence of <i>Borrelia burgdorferi</i>Semantic proximity Read

Natural selection and recombination at host-interacting lipoprotein loci drive genome diversification of Lyme disease and related bacteria.Semantic proximity Read

Ancient <i>Borrelia</i> genomes document the evolutionary history of louse-borne relapsing feverSemantic proximity Read

Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms.Semantic proximity Read