Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination.

doi:10.1371/journal.ppat.1011243

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Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination.

PLoS pathogens - 1 Aug 2023

Lemieux Jacob E, Huang Weihua, Hill Nathan, Cerar Tjasa, Freimark Lisa, Hernandez Sergio, Luban Matteo, Maraspin Vera, Bogovič Petra, Ogrinc Katarina, Ruzič-Sabljič Eva, Lapierre Pascal, Lasek-Nesselquist Erica, Singh Navjot, Iyer Radha, Liveris Dionysios, Reed Kurt D, Leong John M, Branda John A, Steere Allen C, Wormser Gary P, Strle Franc, Sabeti Pardis C, Schwartz Ira, Strle Klemen

Abstract excerpt

Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic elements underlying these associations are not known. Here, we report the whole genome sequence (WGS) and analysis of 299 B. burgdorferi (Bb) isolates derived from patients in the...

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PMID: 37651316
DOI: 10.1371/journal.ppat.1011243
PMCID: PMC10470944

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