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Investigating the Causal Link Between Serum Iron Status and Pernicious Anaemia Risk: A Mendelian Randomisation Study

2024-10-29

Abstract excerpt

<h4>Introduction</h4> Pernicious anaemia (PA) is characterised by vitamin B 12 deficiency due to autoimmune-mediated destruction of gastric parietal cells and the consequent loss of intrinsic factor. A considerable proportion of PA patients also exhibit iron deficiency (ID), both before or at (20.7-52%) and after (46.4%) PA diagnosis. However, findings from observational studies do not clarify whether ID contribut...

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Literature Corpus work
5d590cb2-b7d5-5699-baf9-1d9a9da5d69e
DOI
10.1101/2024.10.28.24316258
Open publication

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