Ephrin-A5 or EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma <i>in vitro</i>

Abstract excerpt

Rhabdomyosarcoma (RMS) is a tumor which resembles skeletal muscle. Current treatments are limited to surgery and non-targeted chemotherapy, highlighting the need for alternative therapies. Differentiation therapy uses molecules that act to shift the tumor cells’ phenotype from proliferating to differentiated, which in the case of skeletal muscle includes exit from the cell cycle and potentially fusion into myofibe...

Topics

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• Forkhead Box Protein O1
• Forkhead Transcription Factors
• Hedgehog Proteins
• Myoblasts
• Paired Box Transcription Factors
• PAX3 Transcription Factor
• ras Proteins
• Rhabdomyosarcoma

Identifiers and source

Literature Corpus work

5d2993b2-0f3a-54d5-a554-64401f7fb161

DOI

10.1101/2024.12.23.629471