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Article

Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

27 Feb 2014

Abstract excerpt

BACKGROUND: Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to a dismal outcome. The histone methyltransferase EZH2 epigenetically suppresses skeletal muscle differentiation by repressing the transcription of myogenic genes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24575771
DOI: 10.1186/1471-2407-14-139

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